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Study of the molecular mechanisms that regulate the establishment of polarized projections

Project description

The mechanisms involved in brain development, including the guidance of migrating neurons, have been extensively studied over the past two decades. However, how neuronal morphology is regulated, in particular the establishment of the exact number of neuronal projections, remains poorly understood. We have discovered new molecular actors that play a key role in these steps: heparan sulfate proteoglycans (HSPG). To study the role of HSPGs and their partners, we use molecular genetics and fluorescence microscopy approaches in vivo using the C. elegans model. This nematode allows cellular and molecular analysis with single-neuron resolution. Our studies will elucidate mechanisms controlling the development of an appropriate polarized morphology of neurons and other cells. They will help to better understand the molecular bases of some orphan diseases that affect the balance between the structure and function of some cell types, such as the microvillus inclusion disease. Our work will also help to characterize the impact of guidance signals and their receptors involved in rare human genetic diseases, such as Rett-atypic syndrome and congenital mirror movement disorder.

Research Team

Name: Raphaël Dima, M.Sc.
Supervisor: Claire Bénard (UQAM)
Laureate: Doctoral fellowship 2018 and 2020

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