Professionals at your service
Consulting and project development
We offer a personalized project development and consultation service
Please contact us for more information.
Steve Bourgault, PhD
Director
Phuong Trang Nguyen, PhD
Manager
Alexandre Brisson, MSc
Research Professional
In silico Protein Interaction Screening Pipeline
The in silico protein interaction screening service is performed using the computing servers of the Digital Research Alliance of Canada and the AlphaFold 3 artificial intelligence software. We predict and classify the interactions between your protein of interest and all the proteins in one or more targeted cellular compartments, and even against interactions confirmed in vitro. Training and support are offered for interpreting the generated results and for data transfer.
In silico Molecular Docking Screening
The in silico screening service enables the modeling of the molecular docking of small molecule libraries in the active site of a target protein. Comprehensive support is offered, including training and access to the MOE software.
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
Usage fee of $50/hour.
Usage fee of $110/hour.
An administrative fee of 15% may apply.
Surface Plasmon Resonance (SPR) – Biacore T200
The versatile surface plasmon resonance apparatus allows the study of biomolecular interactions without protein modification; 1/ characterization of protein-protein, protein-DNA / RNA, protein-ligand interactions, 2/ Determination of kinetic binding parameters (kon, koff), 3/ determination of thermodynamic binding parameters (KD, ΔG, ΔH, ΔS). Precise and high sensitivity analyzes (results analysis software: Biacore T200 Evaluation).
Detection chips allowing immobilization modes:
- Covalent: amines, thiols, aldehydes
- Capture: biotin, His-tag
- Hydrophobic: single and double layer
- Possibility of custom attachment method
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
$50 /hr for use and $50 /hr for technical assistance, excluding the cost of microchips
140$ /h of use and 90$ /h of technical assistance, excluding the cost of microchips
An administrative fee of 15% may apply.
Coming soon - Surface Plasmon Resonance (SPR) Analysis – Biacore 1S+
Accelerate assay development, result generation, data evaluation and interpretation, reducing your analysis cost.
- Multi-complex applications
- 96 and 384 microplates, standard formats and deep wells (up to 2 m)
- Temperature adjustable to 4 °C
- High sensitivity screening
- Lower surface densities, fewer secondary interactions and more target accessible for binding.
- Low affinity analysis (KD in the millimolar range)
- Large multidomain targets or rare or sensitive targets (e.g. G-protein coupled receptors)
Circular dichroism spectrometer - JASCO J-1500 New
This circular dichroism spectrometer enables rapid, simple, and non-destructive analysis of protein, DNA/RNA structures, their conformational transition induced by interactions, and their thermodynamic stability.
- Standard CD, LD and absorbance measurement, and up to 4 simultaneous measured modes when combined with sampling accessories; measurement of liquids to solid-state films.
- Thermal fusion conformation and folding studies
- Vacuum-UV and NIR spectra via PMT (163 – 950 nm) and InGaAs (up to 1600 nm) detectors
- High resolution and S/N performance
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
$20 /hr in stand-alone use or $50 /hr with technical assistance.
$55 /hr of use or $110 /hr with technical assistance.
An administrative fee of 15% may apply.
Affinity ITC
Characterizes serotype and drug load in AAVs and LNPs, as well as target and off-target binding interactions. The Affinity ITC is a powerful tool for measuring a wide variety of molecular interactions. It offers both inexperienced and advanced ITC users the utmost confidence in generating superior ITC data.
- Efficient mixing and maximum sensitivity with AccuShot™ and FlexSpin™ technologies
- Sample volume: 1mL or 190 uL
- Increased limitation of run-to-run carryover
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
$30 /hr in stand-alone use or $30 /hr with technical assistance.
$140 /hr of use or $90 /hr with technical assistance.
An administrative fee of 15% may apply.
TECAN M1000 Plate Reader
Various cellular and enzymatic assays, including AlphaScreen and AlphaLISA technologies
- High throughput screening and analysis
- Absorbance
- AlphaScreen
- AlphaLISA Luminescence
- TR-FRET
- BRET 1-2-3
- Fluorescence polarization
- Fluorescence from above and below
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
$15 /hr for stand-alone use or $30 /hr with technical assistance *.
* excluding the cost of consumables.
$55 /hr for stand-alone use or $90 /hr with technical assistance *.
* excluding the cost of consumables, and administrative charge of 15% may be applicable.
Coming soon - Nanosight Pro
Simple and fast single particle tracking analysis solution to characterize nanomaterials and biomaterials.
- Efficient, fast and user-friendly single particle tracking
- Size: 10 nm to 1000 nm, including biological and low-scattering particles.
- Concentration: 106 to 109 particles per mL
- Minimum sample volume: 250 μL
- Light scattering and fluorescence detection
Purification system – Waters
The Waters automatic purification system offers the specificity of directed purification through the inclusiveness of a UV system. With this state-of-the-art system, it is possible to purify small molecules and peptides.
- Purification capacity up to 200 mg of sample
- Reverse phase purification (RP-HPLC) by C4 or C18 column
- Direct analysis by analytical HPLC from certain samples
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
$75 /hr with technical assistance, excluding the cost of consumables.
$150 /hr with technical assistance, excluding the cost of consumables
Administrative charge of 15% may be applicable.
Peptide synthesis
Synthesis of peptides, unnatural peptides, including fluorescent analogs, isotopically labeled peptides (15N, 13C) and post-translational modifications, such as phosphorylation and palmitylation
Synthesis of peptide of 8 to 50 residues with purification by RP-HPLC (purity >98% guaranteed), and characterization by mass spectrometry (ESI-TOF). Production of 10mg.
Price
CERMO-FC members and UQ network researchers are invited to contact us to find out about privileged rates thanks to the support of CERMO-FC.
- Synthesis with purity >98%, 10mg:
- 8-30 residue peptide: $35 /amino acid*
- 31-40 residue peptide: $40 /amino acid*
- 41-50 residue peptide: $45 /amino acid*
*For synthesis with special amino acids (N15, C13, unnatural) and other modifications (fluorophores, pegylation, phosphorylation), please contact us for a quote.
Synthesis with purity >98%, 10mg:
8-30 residue peptide: $45 /amino acid*
31-40 residue peptide: $50 /amino acid*
41-50 residue peptide: $55 /amino acid*
*For synthesis with special amino acids (N15, C13, unnatural) and other modifications (fluorophores, pegylation, phosphorylation), please contact us for a quote.
An administrative charge of 15% may be applicable.
Recommendations
We used the plate reader on this platform, which is very easy to book and use. The technical staff are also very pleasant and professional.
FAQ - Frequently Ask Questions
Fill out the “Service Request” form at the top of this page or contact us.
Contact us for a free consultation. Together we will assess the feasibility of your project, and we will discuss how to achieve your goals. Then, we will discuss the steps needed to start your project.
The analysis time of your data depends on your needs. The order of service requests is based on the date samples are received.