Project description
Secondary haemophagocytic lymphohistiocytosis (HLH) (ORPHA: 158041) can occur at any age, often as a result of various infections, including leishmaniasis. It is characterized by an exacerbated immune response, especially by macrophages (also called histiocytes), leading to uncontrolled tissue damage. However, the exact causes and mechanisms are still unknown. Our work is based on the hypothesis that infection-induced emergency haematopoiesis contributes directly to the pathogenesis of HLH by promoting accumulation of macrophages responsible for bone marrow destruction and failure. We will use the intradermal mouse ear infection model by Leishmania major to better understand the involvement of hematopoiesis in HLH pathogenesis. We will quantify cell populations as well as cytokines/chemokines present in bone marrow and other hematopoietic organs in the context of either self-healing or chronic infection by different strains of the parasite. These data will help us identify those populations that may contribute to parasite persistence and the development of HLH. Subsequently, these populations can be eliminated to determine their actual importance. Our work will allow us to better understand the immune processes involved in the development and pathogenesis of secondary HLH.
Research team
Name: Fabio Luiz Bandeira Ferreira, B.Sc
Supervisor: Krista Heinonen (INRS)
Laureate: Master scholarship 2019