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Pause-conférence | Pr Andrés Finzi (CRCHUM)

16 janvier 2020 @ 12:00 - 13:00 EST

Exposition à Env: implications dans la lutte contre le VIH

Le Pr Andrés Finzi, professeur au Centre de recherche du CHUM, sera l’invité du Pr Benoit Barbeau, membre régulier du CERMO-FC, le Jeudi 16 janvier à 12h00 en PK-1140.

En savoir plus sur les recherches du Pr Finzi.


Exposing Env: implications in the fight against HIV

Pr Andrés Finzi, a professor at CHUM Research center, will be the guest of Pr Benoit Barbeau, a regular member of CERMO-FC, on Thursday, January 16 at 12:00 in PK-1140.

Learn more about Professor Finzi’s research.

Summary : The HIV-1 envelope glycoprotein trimer (Env) represent the only virus-specific antigen exposed on the surface of virions and infected cells. As such, Env is the main target for neutralizing antibodies and antibody-dependent cellular cytotoxicity (ADCC).  In its unliganded form, Env samples a “closed” conformation which has been referred as State 1.  Broadly neutralizing antibodies (bNAbs) preferentially recognize this particular conformation.   CD4 engagement drives Env into an intermediate “partially open” State 2 conformation and then into the “open” State 3.  Emerging evidence suggest a link between Env “open” conformations and the elimination of HIV-1-infected cells via ADCC.  We will discuss new strategies aimed at stabilizing these “open” conformations and their implication in the fight against HIV-1.

Biography : Dr Andrés Finzi is an associate professor at Université de Montréal and holds the Canada Research Chair on Retroviral Entry.  Dr Finzi did his graduate studies at Université de Montréal.  He then moved to Boston for his postdoctoral training at the Dana-Farber Cancer Institute, Harvard Medical School. In 2011 he was recruited by Université de Montréal and the CRCHUM to expand his research program on HIV-1.   Through their innovative approach to studying the virus, Dr Finzi and collaborators have proudly reached a major breakthrough which might be important in the fight for a functional cure.  Dr Finzi and his team are funded by the Canadian Institutes of Health Research, Canada Research Chairs, Fonds de Recherche du Québec en Santé, American Foundation for AIDS Research and the National Institutes of Health.

 

 

 

 

Un évènement organisé dans le cadre des Pause-conférences du CERMO-FC et soutenu par :
An event organized as part of the Pause-conférences of CERMO-FC, and support by :

 

 

 

Détails

Date :
16 janvier 2020
Heure :
12:00 - 13:00 EST

Lieu

PK 1140
201 avenue du président kennedy
Mtl, Qc H2X 3Y7 Canada
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