Cellular analysis platform
Mass spectrometry platform
Biophysical analysis and functional screening platform
- High throughput screening (customer’s library)
- Various cellular and enzymatic assays, including AlphaScreen and AlphaLISA technologies.
- Characterization of protein-protein, protein-DNA / RNA, protein-ligand interactions.
- Determination of binding kinetic parameters (kon, koff) and affinity (KD)
- Determination of the thermodynamic parameters of binding (DG, DH, TDS) and affinity (KD)
- Structural transition studies induced by interactions
- Determination of binding energies by stability study of biological complexes
- Synthesis of peptides, non-natural peptides, including fluorescent analogs, isotopically labeled peptides (15N, 13C) and post-translational modifications, such as phosphorylation and palmitylation.