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PLATFORMS SERVICES

Transgenesis and genome editing platform

  • Production of transgenic mice
  • Sperm or embryos cryopreservation
  • IVF for in vitro validation or restoration of lines
  • Reimplantation.

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Genomics platform

  • Sample preparation for sequencing
  • Preparation of genomic and metagenomic sequencing libraries
  • High throughput sequencing
  • Consultation and development of molecular studies.

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Bio-informatics platform

  • DNA-Seq analysis
  • RNA-Seq analysis
  • Metagenomic analysis
  • User support
  • Visualization of data and results
  • Functional analysis
  • Interpretation of the results of analysis.

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Cellular analysis platform

  • Fixed or real-time histological imaging
  • Analysis of the expression of a membrane protein in a cell suspension
  • Isolation of a cell subpopulation from one or more membrane markers
  • Provision of a vibratome and cryostat for histological sections of paraffin or frozen tissue.

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Mass spectrometry platform

  • Detection of proteins (non-targeted proteomic analysis)
  • Metabolite analysis in biological samples (metabolomics)
  • Drug metabolism analysis (in vitro or in vivo samples)
  • Quantification of small molecules and peptides
  • Exact mass confirmation (with targeted elementary formula).

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Biophysics and biomolecular screening platform

  • High throughput screening (customer’s library)
  • Various cellular and enzymatic assays, including AlphaScreen and AlphaLISA technologies
  • Characterization of protein-protein, protein-DNA / RNA, protein-ligand interactions
  • Determination of binding kinetic parameters (kon, koff) and affinity (KD)
  • Determination of the thermodynamic parameters of binding (DG, DH, TDS) and affinity (KD)
  • Structural transition studies induced by interactions
  • Determination of binding energies by stability study of biological complexes
  • Synthesis of peptides, non-natural peptides, including fluorescent analogs, isotopically labeled peptides (15N, 13C) and post-translational modifications, such as phosphorylation and palmitylation
  • Synthesis of small molecules.

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